06/26/2026
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Wiseguys Comedy Las Vegas
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Wiseguys Comedy Las Vegas is a vibrant comedy club and restaurant situated in two prime locations within the Arts District and Town Square of Las Vegas. This unique venue combines the lively atmosphere of a comedy show with the culinary delights of a full-service restaurant, attracting both locals and visitors alike. It is conveniently located on S. Main Street, making it an ideal stop for those seeking entertainment alongside dining.
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Address
6593 S. Las Vegas Boulevard Suite B-222
Las Vegas, NV
89119
**Travel Directions to S. Main Street, Las Vegas**
**By Public Transport:**
1. **Bus:**
- Take the RTC bus route that services S. Main Street. Check the RTC website or app for the most current routes and schedules.
- Get off at the nearest stop to S. Main Street.
2. **Monorail:**
- If you are near a Monorail station, take it to the nearest station and transfer to a bus or rideshare service to reach S. Main Street.
3. **Rideshare:**
- Use rideshare apps like Uber or Lyft for direct transport to your destination.
**Driving/Parking:**
1. **Driving:**
- From the Las Vegas Strip, head south on Las Vegas Boulevard.
- Turn left onto E Charleston Blvd and continue until you reach S Main Street.
- Turn right onto S Main Street.
2. **Parking:**
- Look for nearby parking lots or street parking options along S Main Street.
- Some venues may offer designated parking areas; check in advance for availability and any associated fees.
Always check local traffic conditions and public transport schedules before heading out!
Opening Hours
| Wednesday | 6pm - 10pm |
| Thursday | 6pm - 11pm |
| Friday | 6pm - 11pm |
| Saturday | 6pm - 11pm |
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Wiseguys Comedy Las Vegas is a vibrant destination that seamlessly blends the excitement of live comedy with a delightful dining experience. Nestled in the Arts District, this comedy club offers an inviting atmosphere where laughter and good food come together.
With its prime location on S. Main Street, Wiseguys is surrounded by a dynamic mix of restaurants, bars, and shops, making it the perfect spot for a night out. Whether you're looking to enjoy a hearty meal before the show or unwind with friends over drinks after an evening of laughter, Wiseguys has something for everyone.
The club features an impressive lineup of talented comedians, ensuring that each visit is filled with fresh humor and entertainment. It's an ideal venue for both locals and visitors seeking to experience the lively spirit of Las Vegas nightlife. With its unique combination of comedy and cuisine, Wiseguys Comedy Las Vegas promises an unforgettable outing that will leave you smiling long after the final punchline!